PTGS2 and colitis: In addition, Hericium erinaceus low molecular mass polysaccharide (HEP10) significantly ameliorated DSS-induced colitis by inhibiting the induction of pro-inflammatory cytokines iNOS and cyclooxygenase-2 (COX-2), as well as inhibiting the activation of gut flora-associated NLRP3 inflammasome vesicles (129).