In neonatal rat models of hypoxic-ischemic brain injury (HIE), CGA promoted Nrf2 nuclear translocation, suppressed NF-κB activation, and upregulated heme oxygenase-1 (HO-1), silent information regulator 1 (Sirt1), and IκBα. The gene discussed is HMOX1; the disease is perinatal asphyxia.