In SLE patients, probiotic‐treated DCs significantly upregulated FOXP3 expression compared to healthy controls (P‐DEL: p ≤ 0.0001; P‐RAM: p ≤ 0.0001; P‐MIX: p = 0.0081) and the LPS group (p ≤ 0.05). This evidence concerns the gene FOXP3 and systemic lupus erythematosus.