IFNG and systemic lupus erythematosus: In SLE, diminished Treg numbers and function, coupled with heightened pro‐inflammatory Th1 and Th17 cell activity, drive autoimmunity through elevated interferon‐gamma (IFN‐γ) and interleukin‐17 (IL‐17) production, exacerbating tissue damage (Khorasani et al. 2019; Dolff et al. 2011; Huang et al. 2024).