PDGFs and their corresponding receptors, PDGFRα and PDGFRβ, exhibit expression in a diverse range of malignant tumors, such as non-small cell lung cancer (NSCLC), gastrointestinal stromal tumor (GIST), pancreatic cancer, breast cancer, ovarian carcinoma and hepatocellular carcinoma (Pandey et al., 2023). The gene discussed is PDGFRB; the disease is gastrointestinal stromal tumor.