PFN2 and colorectal cancer: Through dysregulated production of cytoskeletal proteins such as fibroblast growth factor, fascin-1, radixin, abelson interactor gene-2, and profilin-2, previous research has demonstrated evidence that the actin-cytoskeleton pathway plays a crucial role in inflammatory bowel disease and colorectal cancer (Tsai et al., 2007; Kanaan et al., 2010).