NFE2L2 and Venous thrombosis: Fisetin, a flavonol, notably blocks inflammatory signaling pathways mediated by MAPK and boosts the nuclear factor erythroid 2-related factor 2 (Nrf2) signal pathway, stimulating the production of various antioxidant enzymes to provide protective effects against oxidative damage on vessels and adjacent tissues, and thus treating deep venous thrombosis in mice inflicted by the surgical ligation of the inferior vena cava (28).