ESR2 and Thrombocytopenia: Genistin enhanced the transcriptional activity of nuclear estrogen receptor beta (ERβ) through activation of membrane receptor-mediated PI3K/Akt and MEK/ERK signaling pathways, and promoted megakaryocyte differentiation and thrombopoiesis through direct binding to ERβ, hence ameliorating X-ray-caused thrombocytopenia in mice (65).