JAK2 and neoplasm: 5,7,4’-trimethoxyflavone, a variant of flavone, is able to bind to leucine-rich PPR motif-containing proteins, STAT3, and cyclin dependent kinase (CDK) 1, which subsequently disintegrates the associations of LRPPRC-janus kinase (JAK)2-STAT3 and JAK2-STAT3-CDK1, thereby hindering the progression of ESCC by disrupting the associated protein complexes, thereby preventing tumorigenesis and inhibiting tumor growth (44).