SMO and bladder transitional cell carcinoma: The introduction of orientin applied to T24 human transitional cell bladder carcinoma cells significantly decreased the levels of shh, p-smo, smo and Gli2 associated with the hedgehog signaling pathway, along with decreasing the expression of p-p65, which serves as an activator for the NF-κB signaling cascade, suppressed the growth of cells while enhancing cell apoptosis (75).