GPX2 and colorectal carcinoma: Cudraflavone C, a type of flavonoid, has the capacity to hamper the expression of downstream pro-oncogenes by inhibiting either the GPX2 expression or activity, blocking GPX2-dependent activation of the Wnt/β-catenin pathway, inhibiting downstream pro-carcinogenic gene expression, thus demonstrating a shielding effect against CRC (61).