5,7,4’-trimethoxyflavone, a variant of flavone, is able to bind to leucine-rich PPR motif-containing proteins, STAT3, and cyclin dependent kinase (CDK) 1, which subsequently disintegrates the associations of LRPPRC-janus kinase (JAK)2-STAT3 and JAK2-STAT3-CDK1, thereby hindering the progression of ESCC by disrupting the associated protein complexes, thereby preventing tumorigenesis and inhibiting tumor growth (44). This evidence concerns the gene STAT3 and esophageal squamous cell carcinoma.