Previous studies have shown that MM cells can mediate the “bone marrow homing” effect through the surface CD44 and CD147 molecules, Western blot analysis and flow cytometry showed that BTZ@PLGA/EM nanocapsules retained CD44 and CD147 proteins on the membrane of MM cells (Figures 2g,h; Supplementary Figure S3). This evidence concerns the gene CD44 and Miyoshi myopathy.