Hocking et al., who conducted open-label, primary-care translation of the DiRECT TDR protocol among adults 20-65 years with T2DM for duration ≤6 years, BMI >27 kg·m−2, and not on insulin, found that at 12 months, 86 of 155 participants (56%) achieved diabetes remission (HbA1c <6.5% and no glucose-lowering medication for ≥2 months) [29]. The gene discussed is INS; the disease is type 2 diabetes mellitus.