The diagnosis of LAM requires a compatible clinical history, characteristic high-resolution chest CT (HRCT) changes, along with at least one of the following: presence of tuberous sclerosis complex (TSC), renal angiomyolipoma, elevated serum vascular endothelial growth factor-D (VEGF-D) ≥800 pg/mL, chylous effusion, lymphangioleiomyomas, demonstration of LAM cells or clusters in effusions or lymph nodes, or histopathological confirmation from lung or extrapulmonary biopsy [2]. The gene discussed is VEGFD; the disease is tuberous sclerosis.