Cytokine release syndrome (CRS): Activation of T cells by bispecific antibodies may provoke an excessive immune response, resulting in the massive release of cytokines such as IL-6 and IL-1β, which can manifest as fever, hypotension, and organ dysfunction (128).In preclinical studies of EGFR/CD3bispecific antibody, the severity of CRS has been found to correlate with the extent of T-cell activation. Here, IL1B is linked to congenital rubella syndrome.