This complex simultaneously downregulates the epithelial marker E-cadherin—whose loss disrupts intercellular adhesion among Tumor Cells and reduces cell cohesion (55)—and upregulates mesenchymal markers such as N-cadherin and vimentin, thereby enhancing the motility and stromal invasiveness of Tumor Cells (56).Multiple clinical studies have demonstrated a significant association between the activation level of this pathway and the depth of invasion in cSCC, underscoring its critical role in tumor progression (57, 58). This evidence concerns the gene VIM and neoplasm.