CDH2 and neoplasm: This complex simultaneously downregulates the epithelial marker E-cadherin—whose loss disrupts intercellular adhesion among Tumor Cells and reduces cell cohesion (55)—and upregulates mesenchymal markers such as N-cadherin and vimentin, thereby enhancing the motility and stromal invasiveness of Tumor Cells (56).Multiple clinical studies have demonstrated a significant association between the activation level of this pathway and the depth of invasion in cSCC, underscoring its critical role in tumor progression (57, 58).