As a result, Tumor Cells are able to survive and proliferate within a relatively “safe” immune environment, enabling the realization of Immune Evasion (39).immune cells (such as tumor-associated macrophages TAMs) have been shown to secrete Cytokines (such as IL-1β and IL-18), which promote the proliferation and metastasis of Tumor Cells (38). The gene discussed is IL18; the disease is neoplasm.