We hypothesize that the first two cycles of chemotherapy, by inducing immunogenic cell death, creates a pro-inflammatory microenvironment and rapidly expands the pool of tumor-reactive T cells, as evidenced by the significant early surge in tumor-infiltrating lymphocytes (TILs) and CD8+ T cell proportions observed after just one cycle of neoadjuvant chemotherapy (NAC) (28). This evidence concerns the gene CD8A and neoplasm.