EDN1 and Hepatic fibrosis: There’re various pro-fibrogenic mediators including TGF-β1, platelet-derived growth factor (PDGF), endothelin-1 (ET-1), toll-like receptor 4 (TLR4) and reactive oxygen species (ROS), stimulating the epithelial to mesenchymal transition, resulting in the secretion of elastin, collagen, proteoglycans and glycoproteins, which play essential roles in liver fibrosis (24).