CHN1 and early-onset autosomal dominant Alzheimer disease: Moreover, CHN1 has been implicated in neurodegenerative diseases, such as Alzheimer’s disease and Parkinson’s disease (60, 61), and has shown to have differential expression in inflammatory disorders like asthma (62), psoriasis (63), and dermatomyositis (64), suggesting a role in neuro-immune signaling linking peripheral inflammation to the neural function.