For example, cutaneous inflammation in AD can gradually promote the progression of allergic colitis through multiple pathways, including the succinate-Tuft cells-IL-25-ILC2s axis, mitochondrial DNA-STING signaling pathway, and the TSLP-eosinophil axis, which all mediate organ-to-organ communication through the circulation (51, 52). Here, IL25 is linked to Alzheimer disease.