Some SAIDs are monogenic and are collectively referred to as Hereditary Recurrent Fevers (HRFs), including Familial Mediterranean Fever (FMF), Tumor necrosis factor Receptor-Associated Periodic fever Syndrome (TRAPS), Mevalonate Kinase Deficiency (MKD), and Cryopyrin-Associated Periodic Syndromes (CAPS) (3–5). Here, NLRP3 is linked to familial Mediterranean fever.