Supplementary File 1 contains detailed methods of all analyses. Spatial interaction analysis revealed a co-clustering pattern of CD11c myeloid cells with CD8+ T cells (Figure 3g). In summary, harvested tissue contained a viable melanoma with surrounding pathological findings suggestive of ongoing immune activation, along with CLL/SLL deposits, and was highly enriched by T-myeloid cell network along with CD8+CD69+ and stem-like T cells. Here, CD8A is linked to B-cell chronic lymphocytic leukemia.