TLR1 and Lyme disease: Previously, we demonstrated that Lyme disease patients with both copies of TLR1-1805G SNP had significantly higher levels of inflammatory mediators, including IL-6, CXCL9, and CXCL10, in serum or joint fluid compared to those with only one copy (1805TG) or those with ancestral/reference alleles (1805TT) (17).