TLR1 and erythema multiforme: Of interest, the frequency of TLR1-1805GG in European patients with EM in this study, the majority of whom are infected with B. afzelii, was similar to that in U.S. patients with EM in our previous study (51%) (17), the majority of whom were infected with B. burgdorferi, suggesting that the Borrelia species alone were not the major contributor to differences in TLR1-1805GG frequency among these cohorts.