To understand how modulated SMCs differ in CAV and CAD, we subclustered modulated SMCs and identified 4 unique subpopulations, with cell composition analysis showing enrichment of the IFN-signature (CXCL9, IFI27) subset in CAV and an enrichment of the APOE subset in CAD (Supplemental 2B, C). Here, APOE is linked to coronary artery disorder.