C2 and systemic lupus erythematosus: We curated a list of canonical systemic lupus erythematosus (SLE) related transcripts including HLA genes (HLA-DRB1, HLA-DRA, HLA-DQB1), early complement genes (C1QA, C1QB, C1QC, C2), B cell signaling and development genes (BANK1, BLK), IFN signaling genes (IRF5, TYK2, STAT4, PTPN2, IFIH1, IRF7, IRF8), T cell regulatory genes (CD274, CTLA4) and immune complex clearance receptor genes (FCGR2A, FCGR3A) from a publicly available dataset36.