At the FANCI locus, which encodes a key component of the Fanconi anemia DNA repair pathway essential for maintaining genomic stability130, the ATAC-seq signal was strong in astrocytes from ages 22, 24, 32, and 34 but markedly reduced in those from ages 53, 56, 72, and 73 (Figure S3c). Here, FANCI is linked to Fanconi anemia.