TP53 and acquired polycythemia vera: We utilized mice with inducible expression of Jak2V617F in the hematopoietic system (Vav-Cre;Jak2V617F/+ = “Jak2V617F”), which generate a PV-like phenotype, or wild-type (WT) control mice as a host background and Tet2 heterozygous loss-of-function (Vav-Cre;Tet2fl/+ = “Tet2Δ/+”) or Tp53 heterozygous knock-in (Tp53R172H/+) mice as the competing test populations.