Following MOG-induced EAE, these mice exhibited clinical features identical to Socs3ΔLysM mice, including severe cerebellar demyelination, increased cerebellar infiltration of activated neutrophils and CD4+ T-cells, and clinical symptoms of both btEAE and classical EAE (cEAE), the latter involving the spinal cord (SC). This evidence concerns the gene CD4 and Peripheral demyelination.