Recent research by Thanos’ group has explored the relationship between the endocannabinoid system and dopamine-related reward deficiency behaviors, particularly in the context of cognitive impairment.(35) Fatty acid-binding protein 5 (FABP5) plays a critical role in the brain’s endocannabinoid system by facilitating the intracellular transport of anandamide (AEA) and Δ9-tetrahydrocannabinol (THC), the psychoactive component of cannabis. Here, FABP5 is linked to Cognitive impairment.