Furthermore, upregulated DEGs were enriched in terms and pathways related to metabolism, including the KEGG pathway ‘lipid and atherosclerosis’, including genes such as low-density lipoprotein receptor (LDLR) and POU Class 2 Homeobox 1 (POU2F1), and the ‘Panthothenate and CoA biosynthesis’ pathway, including the genes aldehyde dehydrogenase 3 family member A2 (ALDH3A2) and pantothenate kinase 3 (PANK3) (Figure 4A). Here, PANK3 is linked to atherosclerosis.