CACNA1C and Familial short QT syndrome: Short QT syndrome (SQTS) and Brugada Syndrome (BrS) were first reported in individuals with CACNA1C p.A39V and p.G490R variants in 2007, not long after the definition of TS, however the evidence for such variants as a genetic aetiology of SQTS and BrS is disputed (10–12).