ACSL4 and amyotrophic lateral sclerosis: However, gene expression analysis showed higher expression of fatty acid and triglyceride metabolism genes in the TDP-ALS MDMi compared to sALS MDMi, specifically, DGAT2 was increased in the TDP-ALS MDMi and not sALS MDMi (in addition to FABP4, FADS1, FASN, and ACSL4) although only FASN was significant (p-value < 0.05).