The observed TG alterations are not unique to our study and have been found in ALS patient serum, Parkinson’s Disease iPSC-motor neurons, as well as ApoE4 microglia [63, 113–116], although AD lipidomic studies have found more drastic alterations in phospholipids, sphingolipids, and cholesterol esters [117–120]. Here, APOE is linked to amyotrophic lateral sclerosis.