In a study using both human AD brain tissue and iPSC-derived microglia with different ApoE genotypes (ApoE3/E3 vs ApoE4/E4), microglia with ApoE4/E4 genotype had increased LDs, greater expression of ACSL1 when exposed to fibrillar Aβ and an induction of TG synthesis. The gene discussed is APOE; the disease is Alzheimer disease.