In deubiquitinase cylindromatosis (CYLD) negative host cells Klebsiella infection quickly followed by production of IL8 this happens because in (CYLD) positive cells K. pneumoniae hijacked the (CYLD) thus inhibits NF-κB signaling (Bengoechea & Sa Pessoa, 2019). The gene discussed is CYLD; the disease is Klebsiella Infections.