NFE2L2 and endometrium neoplasm: Specifically, NRF2 is significantly overexpressed in ESC tissues compared to other endometrial tumors and benign tissues, indicating a direct correlation between NRF2 levels and cancer aggressiveness (107) High NRF2 levels in these cancers also confer increased resistance of SPEC-2 cells to chemotherapy drugs like cisplatin and paclitaxel (107).