NRF2 regulates cellular redox balance and interacts with pathways such as phosphoinositide 3-kinase/protein kinase B (PI3K/AKT), Notch, hypoxia-inducible factors (HIFs), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), myelocytomatosis oncogene (MYC), and forkhead box M1 (FOXM1), promoting tumor progression by enhancing EMT, angiogenesis, and immune evasion (18, 150–152). The gene discussed is NFE2L2; the disease is neoplasm.