BRAF and metastatic neoplasm: Multivariate analysis revealed that surgery for metastatic disease was a significant positive prognostic factor (HR = 0.71, 95% CI 0.52–0.97; p = 0.033), while age ≥60 years (HR = 1.37, 95% CI 1.01-1.86; p = 0.042) and wild-type RAS/BRAF status (HR = 0.65, 95% CI 0.43–0.99; p = 0.043) showed associations with OS that were of borderline statistical significance.