According to the American Joint Committee on Cancer/International Union Against Cancer (AJCC) TNM Staging System, Eighth Edition (TNM-8) criteria (18), the 2 -ΔΔ CT>1 of the RRM2 gene in the PTC tissues was used as the cut-off point for the expression level to classify the samples into the high-expression group and the low-expression group, and further analyses showed that, as shown in Supplementary Table 2, we found that the RRM2 expression level was correlated with tumor size (P = 0.0048), which may indicate that RRM2 acts as a potential oncogenic factor in PTC. The gene discussed is RRM2; the disease is neoplasm.