RRM2 and neoplasm: The subcutaneous loaded tumors in nude mice are shown in Figure 6E, Supplementary Figure S5, and the tumor growth curves (Figure 6F, Supplementary Table 3) showed that the experimental group RRM2-OE-TPC-1 had a steeper tumor growth curve and faster volume growth than the control group TPC-1, whereas the growth of tumors grown by the experimental group RRM2-KD-TPC-1 inoculation was significantly slowed down, with a downward shifting of the tumor volume growth curve (P<0.01).