These differential genes were analyzed for GO and KEGG enrichment (Figures 9B, C), and GO was enriched in several biological processes, including DNA replication, regulation of signaling receptor activity, leukocyte chemotaxis and migration, etc. KEGG suggested that the PI3K-Akt signaling pathway and the cell cycle pathway were significantly enriched in the differential genes, and that RRM2 might affect thyroid cancer cell proliferation and survival. This evidence concerns the gene AKT1 and thyroid gland carcinoma.