CCK and Mental deterioration: Hypoxia triggers aberrant expression of neuropeptides like cholecystokinin (CCK)-where altered levels correlate with synaptic damage and cognitive decline in neurodegeneration-and disrupts key signaling pathways: Neuropeptide W impairs the PKA/CREB cascade via GPR7/8 receptors, inhibiting protein glycosylation essential for cognitive function (Nguyen et al., 2024), while melanocortin dysregulation through MC3R compromises the PI3K/AKT survival pathway, exacerbating neuronal apoptosis.