In addition to the finding that ERO1α deficiency can inhibit angiogenesis by increasing N-glycosylation of VEGFA (Varone et al., 2022), ERO1α also induces the S1PR1/STAT3/VEGF-A signaling pathway triggers tumor migration, angiogenesis, invasion, and EMT of hepatocellular carcinoma (Yang et al., 2018). This evidence concerns the gene ERO1A and neoplasm.