Cardiovascular diseases mainly include arrhythmia, heart failure, stroke, etc. ERO1α drives oxidative stress and calcium homeostasis (Chin et al., 2011), and promotes plaque rupture (Zhang et al., 2021) and thrombosis (Jha et al., 2023), ultimately leading to serious consequences such as myocardial infarction and stroke. Here, ERO1A is linked to stroke disorder.