KEGG pathway analysis highlighted key AD associated pathways, such as the PI3K-Akt signaling pathway (KEGG: hsa04151, FDR=6.16×10−10), MAPK signaling pathway (KEGG:hsa04010, FDR=3.41×10−9), thyroid hormone signaling pathway (KEGG: hsa04919, FDR=3.28×10−6), sphingo lipid signaling pathway (KEGG: hsa04071, FDR=2.45×10−5), and neuro-trophin signaling pathway (KEGG: hsa04722, FDR=2.26×10−5) (Figure 5E). This evidence concerns the gene BDNF and Alzheimer disease.