Eight of these fusions were previously reported in ALL (EP300::ZNF384, ETV6::RUNX1, PAX5::ETV6, TCF3::FLI1, TCF3::PBX1, P2RY8::CRLF2, DUX4::IGH, MEF2D::BCL9) and associated with prognostic molecular subtypes (Gu et al., 2019) (Figure 1A). The gene discussed is CRLF2; the disease is acute lymphoblastic leukemia.