Covariates forced into the logit: age, sex, baseline LVEF, baseline NT-proBNP, SBP, BMI, haemoglobin, eGFR, diabetes, hypertension, CAD, atrial fibrillation, COPD, prior HF hospitalisations, loop-diuretic dose day-1. The gene discussed is NPPB; the disease is chronic obstructive pulmonary disease.