MAPK8 and cardiac hypertrophy: In contrast, treatment with simvastatin ameliorated Rac1 GTP-binding, superoxide production, and cardiac hypertrophy in response to AngII in isolated rat cardiomyocytes and rat hearts [60] and treatment with cerivastatin or expression of GDP-locked Rac1T17N inhibited epinephrine-evoked Rac1 activation, cardiomyocyte apoptosis, and JNK signaling [65].