CYBB and myocardial infarction: More recently, cardiomyocyte-specific NOX2 transgenic mice, but not endothelial cell-specific NOX2 transgenic mice, were shown to have worsened survival, fibrosis, and hypertrophy following myocardial infarction, suggesting cardiomyocyte NOX2 mediates most of its pathogenic effects on the heart [83].