RAC1 and persistent truncus arteriosus: Atorvastatin and pitavastatin were shown to reduce membrane-associated Rac1 and active Rac1 levels in response to AngII infusion in rats [59] and treatment with simvastatin [60] or atorvastatin [61] reduced the degree of cardiac hypertrophy in mice subjected to left ventricular pressure overload by TAC.