Aberrant expression of Arp2/3 complex subunits is a central mediator of cancer progression in the context of tumor immune infiltration and immune escape: In hepatocellular carcinoma (HCC), family members including ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, and ARPC5L are upregulated (Huang et al., 2022; Huang et al., 2021). Here, ACTR3 is linked to hepatocellular carcinoma.