INS and type 1 diabetes mellitus: This systematic review aims to collect, analyze, and summarize research papers related to patients with CFRD, patients diagnosed with type 1 diabetes (T1D) who also have CF, patients with CF who do not exhibit recognized glycemic disorders or are at risk of developing CFRD in the era of modern targeted treatment with the use of CFTRm and its influence on metabolic and glycemic control compared to insulin therapy.