Of particular relevance is the fact that a functional interaction has been found recently between these proteins in the context of a murine model of asthma: genetic deletion of mouse ALOX15 exacerbated IL33-induced eosinophilic airway inflammation [87], and it was found that ALOX15-expressing eosinophils are responsible for attenuating inflammation [88]. This evidence concerns the gene IL33 and asthma.