For LPA, a lipoprotein whose function is still poorly understood but which is associated with cardiovascular disease risk [89] and whose components (apolipoprotein(a) and apolipoprotein B-100) are assembled in the liver [90], we report a negative interaction between a different APOE missense variant, rs7412, and rs571848809, an intronic SNP of the LPA gene. This evidence concerns the gene APOE and cardiovascular disorder.