NKAIN2 and Anxiety: Specifically, reduced BDNF signaling has been repeatedly linked to poor sleep quality, reduced slow-wave activity, and vulnerability to mood and anxiety traits.38,39 Additionally, we observed insomnia associations with NKAIN2 ATP-dependent sodium-potassium transport channel that has previously been associated with mood traits40, and CNTNAP5 that belongs to neurexin family and is involved in cell-cell adhesion and neuronal connectivity (Fig 2, Table S3, S7).