Our results showed a number of consistent associations with earlier reported CSDs such as the MEIS1 association with RLS, PAX8 locus with insomnia, FTO locus with sleep apnea, and a remarkably strong association at the HLA locus with narcolepsy providing a proof of principle of robust and reproducible associations across cohorts (Fig 2, Table S3, S5).34–36. This evidence concerns the gene PAX8 and sleep apnea syndrome.