ZFHX3 and cardiovascular disorder: Furthermore, we observed new signals for known RLS loci (BTBD9) but where the lead variants were not in LD with the lead variants from earlier studies.38 Furthermore, we found associations at previously unreported loci, including ZFHX3 that has been implicated in retinal sensitivity and circadian responses to light.41 Other previously unreported associations included NCAPD3 and IQCH, that connect RLS with energy metabolism and cardiovascular disorders that are often comorbid with RLS.42