NPM1 and acute myeloid leukemia: Advanced age has also been identified as a poor prognostic factor, either reflecting increased co-morbidities in the elderly or due to a distinct biology in elderly AML.36,4,8,37,38 Various recurrent molecular mutations have been identified as important prognostic factors as well.39 In particular, FLT3-ITD mutations are considered poor prognostic factors, particularly in the setting of wild-type NPM1.