OLIG3 and Alzheimer disease: When comparing gene expression changes associated with AD risk in ERC to previously published snRNA-seq datasets in other brain regions from patients with AD, we encountered both commonalities, such as E4+ downregulated oligodendrocyte DEGs, and contrasting findings, such as Oligo.3 E4+ upregulated genes enriched in downregulated DEG sets from other cell types17,19.