Candidates for engaging these pathways in the context of Parkinson’s disease pathogenesis include risk genes such as Rab32 and VPS35 that are known to activate LRRK2 and VPS13C that promotes the repair of damaged lysosomes (Gustavsson et al., 2024; Hop et al., 2024; Mir et al., 2018; Wang et al., 2025). The gene discussed is VPS35; the disease is Parkinson disease.