In addition to the aorta, PAI-1 deficiency did not change coronary perivascular fibrosis after 4 weeks of AngII or NE infusion in our study, differing from the protective effect of PAI-1 deficiency against Nω-Nitro-L-arginine methyl ester (L-NAME)-induced perivascular fibrosis (34, 35). Here, SERPINE1 is linked to fibrosis.