SERPINE1 and hemorrhage: While this finding has been reported previously (8, 11–13), our studies, with detailed spatial and temporal exploration, revealed several novel observations: (1) PAI-1 deficiency augmented cardiac fibrosis and promoted ferric iron deposition in both AngII- and NE-infused mice, regardless of sex; (2) PAI-1 deficiency triggered cardiac hemorrhage and cardiomyocyte loss as early as 1 day of AngII infusion; and (3) hemorrhage observed at 1 day and 1 week infusion intervals spatially coincided with augmented fibrosis observed at 1 and 4 week intervals, respectively.