In the two FTD datasets, the cryptic burden score performed comparably to the strongest single-event predictors (RiMOD: Area under curve (AUC) = 1.0; HS6ST3 = 0.998; KCNQ2 = 0.994; NYGC: AUC = 0.967; STMN2 = 0.934; KCNQ2 = 0.934) (data not shown). The gene discussed is STMN2; the disease is frontotemporal dementia.