To broadly characterise TDP-43 CE, we assembled a compendium of previously published and newly generated in vitro TDP-43 KD datasets, including two from neuroblastoma cell lines, five from iPSC-derived neurons, and a complete knock-out in HeLa cells, and performed both differential expression and splicing analyses (Supplementary Tables 1–2). This evidence concerns the gene TARDBP and neuroblastoma.