Similarly, CAD heritability was enriched in smooth muscle cells stimulated with IL-1α (enrichment coefficient= 1.8, P-adj= 2.3×10−8), IL-6+TNF-α (enrichment coefficient=1.8, P-adj=2.3×10−7), and high glucose (enrichment coefficient= 1.5, P-adj= 1.1×10−7). This evidence concerns the gene IL6 and coronary artery disorder.