Furthermore, we assessed evidence from rare coding variation and CAD association for any of the candidate protein-coding genes in the 9p21.3 locus – CDKN2A, CDKN2B, DMRTA1, and MTAP using exome-sequencing data from four large cohorts namely the ExSeq study (N=57,178) and WGSeq study (N=6,809) from the Myocardial Infarction Genetics (40% European, 2% East Asian, 49% South Asian, and 7% African) and the UK Biobank 13K and 200K studies (European ancestry) 55. This evidence concerns the gene CDKN2A and coronary artery disorder.