CXCL9 and neoplasm: Based on GeoMx, the downregulation of Cxcl9 and Cxcl10 was apparent in both tumor and immune compartments in old mice, but with a greater fold change observed in the tumor compartment (tumor: Cxcl10 FC = 4.12, p = 4.35 × 10−11; Cxcl9 FC = 5.69, p = 0.02; immune: Cxcl10 FC = 1.87, p = 0.08; Cxcl9 FC = 3.2, p = 0.06) (Extended Data Fig. 3A).