The results indicated that CASP8, FADD, CASP6, NLRP3, PSTPIP2, TNFAIP3, GSDMD, MLKL, IRF1, AIM2, ZBP1, CASP1, RIPK1, RIPK3, TRADD, MEFV, PYCARD, and NLRC4 were upregulated in ccRCC samples compared to normal samples. Here, IRF1 is linked to nonpapillary renal cell carcinoma.