The results indicated that CASP8, FADD, CASP6, NLRP3, PSTPIP2, TNFAIP3, GSDMD, MLKL, IRF1, AIM2, ZBP1, CASP1, RIPK1, RIPK3, TRADD, MEFV, PYCARD, and NLRC4 were upregulated in ccRCC samples compared to normal samples. This evidence concerns the gene AIM2 and nonpapillary renal cell carcinoma.