NLRP3 and hyperinsulinemic hypoglycemia, familial, 4: While the accumulation of macrophages in diabetic kidneys was accompanied with an increased expression of proinflammatory genes (Tnf, Ccl2, Nos2, Nlrp3 – Table 1) associated with classical M1 macrophage activation, this was not affected by myeloid MR deficiency and was not seen in the diabetic hearts (Table 2).