MR analysis showed that GLP-1 RAs may be associated with a reduced risk of T2D (OR:0.900, 95% CI: 0.863–0.939, P < 0.001) and obesity (OR:0.779, 95% CI:0.733–0.827, P < 0.001) (Figure 7). The gene discussed is GLP1R; the disease is obesity due to melanocortin 4 receptor deficiency.