It could also reduce astrogliosis and microgliosis in the dentate gyrus region of the hippocampus, prevent the impairment of pro-opiomelanocortin and G-protein-coupled receptor 43 expression caused by T2D, and simultaneously increase the number of NeuN+ and GLP-1R neurons in the hippocampus [53]. This evidence concerns the gene RBFOX3 and type 2 diabetes mellitus.