IGHE and anaphylaxis: The glycolipid hypothesis, termed by Román‐Carrasco et al., suggests that the lipid‐associated digestion of alpha‐gal allows for initial protection from degradation or capture by free or mounted IgE, and that chylomicron‐based transport contributes significantly to the later degranulation of effector cells that result in anaphylaxis (Figure 2) [133, 136].