While the pharmacokinetic interaction of licorice with corticosteroids and other drugs due to inhibition of the CYP3A4 isozyme was already included as a herb-drug interaction, the pharmacodynamic interaction between licorice and antihypertensives, including diuretics, leading to a risk of sodium and water retention, hypokalemia, hypertension, particularly in patients with renal disease [40, 41] was added. This evidence concerns the gene CYP3A4 and hypertensive disorder.